砷以許多化學形式出現，具有不同程度的毒性。在飲食中，亞砷酸鹽（AsIII）和砷酸鹽（AsV）形式毒性最大，這兩種形式的砷的總和稱為無機砷（InAs）。美國食品和藥物管理局（FDA）在2008年制定了23μg/ L的蘋果汁中的iAs作為關注的水平，並且如果總砷含量> 23μg/ L，則必須確定砷的種類。 2013年7月，美國食品及藥物管理局（FDA）宣布蘋果汁中含有10微克/升的“行動水平”。 NIST與疾病控制與預防中心和FDA合作開發了蘋果汁中的標準參考物質（SRM）3035砷物種，以滿足食品安全測量的需求。 SRM 3035旨在用於圍繞監管準則和限制測量蘋果汁中的砷物質和總砷的質量保證和方法驗證。 SRM 3035的一個單元由五個2 mL小瓶組成，每個小瓶用一個氧氣吸收器包裝在鍍鋁聚乙烯袋中。每個小瓶含有約1.5mL冷凍蘋果汁。

Arsenic appears in many chemical forms with varying degrees of toxicity. In diet, the arsenite (AsIII) and arsenate (AsV) forms are the most toxic, and the sum of these two forms of arsenic is known as inorganic arsenic (iAs). The U.S. Food and Drug Administration (FDA) established 23 μg/L of iAs in apple juice as a level of concern in 2008, and arsenic species must be determined if the content of total arsenic is >23 μg/L. In July 2013, (FDA) announced an “action level” of 10 μg/L for iAs in apple juice. NIST, in collaboration with the Centers for Disease Control and Prevention and FDA developed Standard Reference Material (SRM) 3035 Arsenic Species in Apple Juice to meet the needs in food safety measurements. SRM 3035 is intended for quality assurance and method validation in the measurement of arsenic species and total arsenic in apple juice around the regulatory guidelines and limits. A unit of SRM 3035 consists five 2 mL vials individually packaged with an oxygen absorber in an aluminized polyethylene pouch. Each vial contains approximately 1.5 mL frozen apple juice.