1989年，NIST在人血清中開發了標準參考物質（SRM）968脂溶性維生素，用於驗證測定人血清/血漿中視黃醇，α-生育酚和β-胡蘿蔔素的方法。由於該SRM的普及和增加的用途，該材料已被重新發布七次（如SRM 968a，SRM 968b，SRM 968c，SRM 968d，SRM 968e，以及作為新開發的材料SRM 968f Fat-Soluble維生素在冷凍人血清中）。 SRM 968f是一種冷凍人血清，由NIST對總視黃醇，α-生育酚和γ-加β-生育酚進行認證的兩個濃度水平組成。還提供了非認證值，以前稱為參考值和信息值。這些數值包括維生素D代謝物的方法特異性結果以及NIST微量營養素質量保證計劃（MMQAP）參與者測量的類胡蘿蔔素和其他維生素相關分析物的一致結果。在MMQAP 34年的生命週期中，NIST的化學科學部及其前身通過開發測量技術，參考材料和實驗室間實驗室，支持臨床和營養界對人體血清中所選脂肪和水溶性維生素及相關分析物的測量技術研究。

In 1989 NIST developed Standard Reference Material (SRM) 968 Fat-Soluble Vitamins in Human Serum for use in validating methods for determining retinol, alpha-tocopherol, and beta-carotene in human serum/plasma. Due to the popularity and increased usefulness of this SRM, this material has since been re-issued seven times (as SRM 968a, SRM 968b, SRM 968c, SRM 968d, SRM 968e, and as the newly developed material, SRM 968f Fat-Soluble Vitamins in Frozen Human Serum). SRM 968f is a frozen human serum and consists of two concentration levels certified by NIST for total retinol, alpha-tocopherol, and gamma- plus beta-tocopherol. Non-certified values, formerly known as reference and information values, are also provided. These values include method-specific results for vitamin D metabolites and consensus results for carotenoids and other vitamin-related analytes measured by participants in the NIST Micronutrients Quality Assurance Program (MMQAP). Over the MMQAP’s 34-year lifetime, NIST’s Chemical Sciences Division and its predecessors supported the clinical and nutritional communities’ measurement technology for selected fat- and water-soluble vitamins and related analytes in human serum through development of measurement technologies, reference materials, and interlaboratory studies.